Laboratory of Biomedical Nanomaterials

14/11/2021 - 03:38 PM 194 views

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CÁC THÀNH TỰU CHÍNH

Director
Assoc. Prof. Ha Phuong Thu

MISSION:

Fundamental and applied research on nanomaterials for bimedical and envirenmental applications

MAIN RESEARCH DIRECTION:

Main research direction: Fabrication and development of biomedical sensing systems, environmental detection, food safety control systems, megnetic nanomaterials for biomedical applications, nano drug velivery systems for cancer prevention and treatment, applications of nanomaterials in agriculture.

thuhp@ims.vast.ac.vn

+84 988 165 677

ACHIEVMENTS

In 2014, with the cooperation between the Institute of Materials Science and CVI Cosmetics Pharmaceutical Joint Stock Company, the Biomedical Nanomaterials Department produced and transferred Nano Curcumin products to the company.
In 2015, CVI Cosmetics Pharmaceutical Joint Stock Company ordered to research the topic "Research on the preparation process of nano-sized drug delivery system: nano (fucoidan-ginseng-curcumin) used in the prevention and support of cancer treatment. hump", 2014-2015. Research funding is provided by CVI Company and Institute of Materials Science.
After finishing the research project ordered by the enterprise, we have successfully fabricated nano (fucoidan-ginseng-curcumin) called FGC nanocomplex with an initial capacity of 15 kg/month.

Figure 1. CumarGold Kare Functional Food Products

From October 2016 up to now, we have transferred FGC nanomaterials to CVI Company to produce CumarGold Kare products for cancer prevention and support.

Figure 2. Technology transfer ceremony of FGC nano-complex products to CVI . Cosmetics Pharmaceutical Joint Stock Company

After the success of the project "Development of nanotechnology in the production of functional foods and commercialization of Nano products (Fucoidan-Curcumin-Ginseng) for cancer prevention and support" funded by Innofund , code VIE 12 047 11/AP/001/FINANCING AGREEMENT/003-W1, December 2016 – December 2017 funded by the Innofund Foundation, with support from the Institute of Materials Science. In 2017, we transferred FGC nanomaterials to CVI Cosmetics Pharmaceutical Joint Stock Company on a scale of 120kg/month, equivalent to 20000 (twenty thousand) boxes of CurmaGold Kare products, with a total cost of about 10 billion VND. Up to now, the product has continued to be transferred to CVI Cosmetics Pharmaceutical Joint Stock Company with a scale of 60kg/month, equivalent to 10,000 (ten thousand) product boxes with a total cost of about 5 billion VND/year and used. in the prevention and support of cancer treatment and received very positive feedback from cancer patients.

SELECTED PUBLICATIONS

Scientific publications

Phuong Thu Ha*, Thi Thu Huong Le, Thi Dieu Thuy Ung, Hai Doan Do, Bich Thuy Doan, Thi Thu Trang Mai, Hong Nam Pham, Thi My Nhung Hoang, Ke Son Phan and Thuc Quang Bui, Properties and bioeffects of magneto–near infrared nanoparticles on cancer diagnosis and treatment, New Journal of Chemistry, 44, 17277-17288 (2020).
Phuong Thu Ha*, Thi Thu Huong Le, Thuc Quang Bui, Hong Nam Pham, Anh Son Ho, Linh Toan Nguyen, Doxorubicin release by magnetic inductive heating and in vivo hyperthermia-chemotherapy combined cancer treatment of multifunctional magnetic nano particles, New Journal of Chemistry; 14, 2019 (IF=3.069)
Thi Thu Huong Le, Thuc Quang Bui, Mai Huong Le, Thi Minh Thi Ha, Hong Nam Pham, Phuong Thu Ha*, Optimizing the alginate coating layer of doxorubicin-loaded iron oxide nanoparticles for cancer hyperthermia and chemotherapy, Journal of Materials Science, 53 (19), 2018, pp 13826-13842. (IF-3.442)
P.H. Nam, N.X. Phuc, D.K. Tung, V.Q. Nguyen, N.H. Nam, D.H. Manh, P.T. Phong, Effect of superparamagnetic interaction on the magnetic heating efficiency of Co0.3Zn0.7Fe2O4 and Co0.5Zn0.5Fe2O4 nanoparticles, Physica B: Physics of Condensed Matter, 591, 412246 (2020).
T. Phong, P.H. Nam, N.X. Phuc, B.T. Huy, L.T. Lu, D.H. Manh, and IN-Ja Lee, Effect of Zinc Concentration on the Structural, Optical, and Magnetic Properties of Mixed Co-Zn Ferrites Nanoparticles Synthesized by LowTemperature Hydrothermal Method, Metallurgical and Materials Transaction A, 50A (2019), 1571–1581.
H. Nam*, L. T. Lu, P. H. Linh, D. H. Manh, Le Thi Thanh Tam, N. X. Phuc, P. T. Phong and In-Ja Lee, Polymer-coated cobalt ferrite nanoparticles synthesis, characterization, and toxicity for hyperthermia applications, New Journal of Chemistry, 42(2018), 14530-14541.

Thi Kim Oanh Vuong*, The Tam Le, Hai Doan Do, Xuan Truong Nguyen, Xuan Ca Nguyen, Thi Thu Vu, Trong Lu Le, Dai Lam Tran, PMAO-assisted thermal decomposition synthesis of high-stability ferrofluid based on magnetite nanoparticles for hyperthermia and MRI applications, Materials Chemistry and Physics, 245, 122762 (2020).
L. H. Nguyen, V. T. K. Oanh*, P. H. Na, D. H. Doan, N. X. Truong, N. X. Ca, P. T. Phong, L. V.Hong, T. D. Lam, Increase of magnetic hyperthermia efficiency due to optimal size of particles: theoretical and experimental results, Journal of Nanoparticle Research, 22(258), 172 (2020)
Wan-Ting Tsai, Minh-Hang Nguyen, Jian-Ren Lai, Hai-Binh Nguyen, Ming-Chang Lee, Fan-Gang Tseng, ppb-Level Heavy Metal Ion Detection by Electrochemistry-Assisted NanoPorous Silicon (ECA-NPS) Photonic Sensors, Sensors and Actuators B: Chemical, Volume 265, 15 July 2018, Pages 75-83.
Cao Thi Thanh, Nguyen Hai Binh, Nguyen Van Tu, Vu Thi Thu, Maxime Bayle, Matthieu Paillet, Jean Louis Sauvajol, Phan Bach Thang, Tran Dai Lam, Phan Ngoc Minh and Nguyen Van Chuc, An interdigitated ISFET-type sensor based on LPCVD grown graphene for ultrasensitive detection of carbaryl, Sensors and Actuators B: Chemical, Volume 260, 1 May 2018, Pages 78-85.

Intellectual Property

“Phương pháp vi bao Curcumin bằng Fucoidan được chiết tách từ rong nâu (Laminaria japonica Aresch) và Saponin từ củ tam thất bắc (Panax notogingseng (Burk.) F. H. Chen) và hệ nano (Fucoidan-Gingseng-Curcumin) thu được theo phương pháp này”, số văn bằng 22424, năm 2019; tác giả: Hà Phương Thư.
"Phương pháp sản xuất phân bón trên cơ sở vật liệu xốp hydroxyapatit mang các nguyên tố đa lượng và vi lượng và phân bón thu được bằng phương pháp này", số văn bằng 25414, năm 2020. Tác giả: Hà Phương Thư, Nguyễn Hoài Nam, Phan Kế Sơn.
“Phương pháp sản xuất vật liệu xốp hydroxyapatit mang phân bón vi lượng và vật liệu xốp hydroxyapatit mang phân bón vi lượng thu được theo phương pháp này”, số văn bằng ĐQSC 24799, Tác giả: Hà Phương Thư.
“Phương pháp chế tạo vật liệu kháng sinh nano Doxycyclin”, số văn bằng GHPI 2671. Tác giả: Hà Phương Thư, Phan Kế Sơn.

FACILITIES

High Power Alternating Magnetic Field Generator Model UHF-20A - Maximum power: 20 kW - Output AC current (Coil current): 30 500A - Frequency: 100 – 450 kHz - Cycle capacity: 100% - Control unit weight: 29kg - Sensor weight: 18kg - Input voltage: 3×380V/50Hz - Cooling water speed ≥ 0.2MPa; ≥6L/min - Control block size (cm): 55L×40W×69H - Touch block size (cm): 45L×30W×40
Microwave system Uwave -1000 - Power supply: 220V, 50Hz - Input power: 2,000W - Microwave output ratio: 0 ~ 1,000W - Microwave operating frequency: 2,450MHz - Output ultrasonic power: 0 ~ 800W - Ultrasonic operating frequency: 26~28KHz - Input power of ultraviolet lamp: 300W

HIGHLIGHTS
Scientific research, technology development, application and transfer of science and technology products and services; international cooperation and training in the field of materials science and technology and other related fields.

28 + Year of establishment
Established on June 11, 1993
240 + staffs
3 Professors, 9 Associate Professors, 13 Senior Researchers, 80 Ph.
Arwards
First Class Labor Medal